Sunday, October 28, 2012

Young millennials: Fiscal conservatives?

CHICAGO (AP) ? This generation of young Americans has been called many things, from civic-minded to "entitled." But fiscally conservative?

That's a new one, and it just might have an impact on the presidential election.

Listen to Caroline Winsett, a senior at DePaul University, who considers herself fairly socially liberal but says being fiscally conservative matters most right now.

"Ultimately, I'm voting with my pocketbook," says Winsett, a 22-year-old political science major who's president of the DePaul student body. She recently cast an absentee ballot for Republican Mitt Romney in her home state of Tennessee.

To be clear, polls show that President Barack Obama remains the favorite among 18- to 29-year-old registered voters, as he was in 2008. No one thinks the majority of young voters will support Romney, a former Massachusetts governor, in the Nov. 6 election.

But the polls also hint at a "schism" between those who weren't old enough to vote in 2008 and their older twenty-something counterparts, says John Della Volpe, the polling director at Harvard University's Institute of Politics.

In one poll, for instance, he found that 42 percent of 18- and 19-year-olds identified as "conservative," compared with just over one-third who said they were "liberal." By comparison, those proportions were nearly flipped for 22- to 24-year-olds: 39 percent said they were "liberal," and a third called themselves "conservative." It was much the same for older twenty-somethings.

Tina Wells, head of Buzz Marketing, an agency that tracks the attitudes of young people, has noticed this shift to the right. Her own researchers have found that the youngest adults are much more likely to label themselves "conservative," ''moderate" or "independent" than older Millennials, a term for young adults who've entered adulthood in the new millennium.

Like a lot of youth experts, Wells thinks it has to do with one thing: the economy.

Suddenly, she says, the "entitled generation," those who grew up in more prosperous times and were seen as having ridiculously high expectations for jobs and standard of living, was no more.

"That bubble burst the minute the economy started tanking, and they were the 'unemployed generation,'" Wells says. "They had to grow up."

She says the recession had a particularly profound effect on the political attitudes of younger Millennials, who've come of age as the adults who preceded them have lost homes, jobs and retirement funds. It has set a decidedly grimmer tone as their age group also has faced the highest unemployment rate of any age bracket, while many others have had to take jobs below their qualifications.

"We heard about how our parents' bank accounts were shrinking and how money that was there one day was gone the next," says Jessie Wurzer, a 17-year-old in Fairport, N.Y.

She says it's left her and her peers "with a lingering anxiety about money and finances in general."

They worry about how they'll afford college, whether Social Security will be there when they're ready to retire and how the national deficit will affect them. That's why Wurzer now calls herself a "fiscal conservative."

At the same time, however, she considers herself a moderate on social issues, including gay marriage and abortion. So in traditional political terms, this generation is hard to peg.

Unemployment is now the top concern among young people, says Deborah Maue, vice president at TRU, a Chicago-based research company that specializes in tweens, teens and young adults. Just after the 2008 election, unemployment ranked fifth, behind such issues as education and health care.

But, Maue, says this is a generation that's also passionately "hands off" on social issues. TRU's research also has found that teens are increasingly uninterested in organized religion.

"They're all about individuality and accepting people as individuals," says Maue, who leads the TRU Enrollment Insights Program for higher education professionals.

For some young people, an interest in individual freedom has sent them to the Libertarian party. Rachel Palermo, a 19-year-old in Northfield, Minn., is one of them.

"Our loss of trust may be why we have the mentality that the economy would be best with less intervention" says Palermo, a sophomore at St. Olaf College. She plans to vote for Libertarian presidential candidate Gary Johnson.

"Even though politician after politician promises they'll improve the economy, they have failed, and we are going to suffer from it."

Republicans also have seen an opportunity here.

In 2008, Republican pollster Kristen Soltis says she watched disappointedly as her party "really let the youth vote go."

This election, that hasn't been the case. Vice presidential candidate Paul Ryan has spent time campaigning on college campuses. George P. Bush, son of former Florida Gov. Jeb Bush, has done the same for the Romney-Ryan ticket in that state.

Soltis also notes that, last summer, during a recall election in Wisconsin, a slight majority of voters in the 18- to 24-year-old age bracket cast a ballot to keep Republican Gov. Scott Walker in office.

"This election is such a huge opportunity for Republicans," says Soltis, who, at age 28, is also a member of the millennial generation.

But it remains to be seen whether Republicans can win over these young voters on social issues, especially when the economy rebounds.

"Either the party will have to persuade more young people or the party will adapt. I don't necessarily know which way that's going to go yet," Soltis says.

Winsett, the DePaul senior, says Republicans would be wise to "shift back to the center" to attract more young people.

Brady Meixell, a freshman at the College of William & Mary in Virginia, agrees.

"People in my age group who would typically be Republicans, and are very fiscally conservative, are disenchanted with the social conservatism of the GOP and don't exactly know where to turn," says Meixell, who's 18 and plans to vote for Obama.

He says Obama has won many students over with college loan reforms and with his health care plan, which allows young people to stay on their parents' insurance into early adulthood.

Meanwhile, 21-year-old Alex Avdakov describes himself as conservative on social issues such as abortion and welfare. But his vote will be driven by what amounts to fiscal conservatism: a concern about government spending.

He plans to vote for Obama because he strongly opposes Romney's plan for military spending, "especially when his entire campaign is centered around reducing the deficit," says Avdakov, a senior at Case Western Reserve University in Ohio.

These mixed emotions help explain why this election is generating much less excitement on college campuses than there was in 2008.

"They're not fully committed to Obama. But they're not fully committed to Romney either," says Della Volpe, the pollster from Harvard.

Or perhaps they're not fully committed to the political process as a whole, but are turned off, as many young people note, by partisan bickering and gridlock.

A recent TRU poll found that more young people answered "don't know" or "don't care" when asked if they were liberal, moderate or conservative.

Six months after the 2008 election, 13 percent of teens and twentysomethings gave that answer. In a recent poll, that "don't know/don't' care" number rose to 27 percent for the entire age group ? and to 36 percent for teens.

That could be bad news for those hoping to build on the last election's banner youth vote numbers. But Maue, at TRU, doesn't necessarily think it means they're disengaged.

"It may mean they're undecided," she says. "So it could go either way."

Source: http://news.yahoo.com/young-millennials-fiscal-conservatives-144054323--election.html

the maldives harper lee mega millions numbers the fray seahawks new uniforms 2012 tornadoes in dallas anchorman 2

3 More Writing Productivity Tips for NaNoWriMo | Kevin J ...

Okay, I won?t make you wait for the rest.? These are the last three of ?Kevin?s Eleven? tips to increase your writing productivity.? I hope you?ve found some of them useful, so you can charge ahead and get your novel done in November.? Start revving your creative engines!

Productivity Tip #9: Think Outside the Keyboard

After the previous tip, now that you?ve set up the perfect established writing spot, keep in mind that this is not the only way you can write. ?Your word processor isn?t the only tool you have.

This technique is one of the most obvious and effective, though least-often attempted, means of increasing writing productivity. ?Think outside the keyboard. ?If you can learn different ways to write, with different tools?like a talented musician learning to play several instruments?you can take advantage of nearly any situation in which you find yourself?and get pages done, no matter where you are.

I have a desktop computer in my office, where I do most of my editing. ?I am just as comfortable working on my laptop whenever I?m away from home?in restaurants, at hotels, on airplanes. But it doesn?t stop there.

Remember the old pad and pencil? ?For those times you find yourself alone in a coffee shop, or riding the bus, or sitting at a picnic table outdoors, you can jot down notes, outline a story, write a rough draft. ?? By hand.

My wife and I once plotted and outlined an entire Star Wars ?Junior Jedi Knights? trilogy using crayons on the butcher-paper tablecloth in an Italian restaurant. Before leaving, we tore off the wide chunk of the paper, folded it, and took it with us as our ?notes.?

For myself, I prefer to do my initial writing with a hand-held recorder. I love to go out hiking on beautiful trails, take inspiration from the scenery around me?and get away from all the interruptions at home. ?Writing by tape recorder allows me to be productive during an already enjoyable outdoor activity. ?Sometimes I just talk myself through plot snags, letting my imagination roam as I develop imaginary biographies for characters or histories for my fictional worlds. Most of the time, though, I dictate finished prose. ?My record (so far) has been composing 45 pages (once they were transcribed) of finished prose in a single, very long, hike.

At work in my ?office?

Speaking finished prose out loud into a voice recorder may be difficult until you get used to the idea. ?Some writers have tried and couldn?t quite get the hang of it; several told me they felt self-conscious walking along and talking to themselves?just pretend it?s a Bluetooth set or a cell phone.? Nobody else knows the difference. ?Face it, nobody learns to type 200 words a minute the first time they touch a keyboard either; it seems unnatural, the keys are in a very strange order, but you get used to it and then pick up speed.? Same with dictation.

At first, I used the recorder just to capture ideas when I went out for a walk. Before I learned to bring the recorder along, I would come up with snatches of brilliant prose, but by the time I hurried back to my keyboard, I?d forgotten it. With practice, though, I now write finished text off the top of my head (which I still polish).

Just today, I headed out for a week-long writing trip in the Utah desert, an eight-hour drive from my home near Colorado Springs.? Since it was mostly interstate driving, with the cruise control on, I could get a lot of thinking done?and a lot of dictating.? On the drive, I dictated 4 chapters in my new ?Seven Suns? novel, THE DARK BETWEEN THE STARS?probably about 6000 words. Now that I?m here in my hotel room, I?ll upload the files to the typing service, while I get to work editing previously transcribed chapters (see, I follow my own Tips).

The view outside of my hotel room at Capitol Reef National Park, Utah

The drawback with a recorder is that someone has to transcribe your words, but if you don?t want to do it yourself, typing services are available to do this for a reasonable fee, even voice-recognition software (although a batch of science fiction terms makes the learning curve rather steep). ?Because of my prolific writing output, I keep my typist busy almost full-time just with transcribing duties. ?I use an Olympus DS7000 digital voice recorder, with the attendant software to download my audio files and email them to the typist.

For a full description of dictation as a writing technique, see my earlier blog, ?Dictating, Writing, Hiking.?

Other people have developed their own unique alternatives to sitting-at-the-typewriter writing. ?Find some for yourself, see what your natural method for storytelling is.

Productivity Tip #10:? Get Inspired!

Every creative writing teacher repeats the classic axiom, ?Write about what you know.? ?Therefore, it stands to reason that the more you know, the more things you?ll be able to write about.

Every experience, class, interesting acquaintance, or place you visit goes into your pantry of ?ingredients? for new material. Part of your job as a writer is to collect these ingredients so that you can use them?by learning new subjects, doing new things, meeting new people, seeing new places. ?You?ll be surprised at how many doors will open for a writer doing research.

Strictly to broaden my knowledge-base of experiences over the years, I?ve taken a hot-air balloon ride, gone white-water rafting and mountain climbing, traveled to various cities and countries, been a guest backstage at rock concerts, attended a world-class symphony, and taken extensive tours of high-tech scientific research installations, visited a giant aircraft carrier, been on the floor of the Pacific Stock Exchange, taken cruises, gone zip-lining, and toured behind the scenes at FBI Headquarters.

Feeling less adventurous? ?Then do other things to get inspired. Read extensively, research esoteric topics, take a class about a subject you know nothing about. ?Watch documentaries at random.? Go to a museum?especially an oddball one.? Sign up for a ballroom dancing group, attend the meeting of a model-rocketry club, go outside at night and learn the constellations.

In your daily life, open your eyes and observe what is around you. Every experience is filled with details to absorb and use at some later time. Watch people. See what they do, observe how they act, listen to how they talk, try to understand who they are and make up biographies for them.

In short, exercise your creative muscles. Go outside your comfort zone.? Stock up your mental pantry with ingredients so that you?ll have a lot to cook with.? You never know what might spark a story idea or an interesting character, and being inspired will add to the energy you can put into your writing.

?

Productivity Tip #11:? Know When to STOP

Science fiction master Robert Heinlein proposed a set of rules for writers. ?His first two are ?You must write? and ?You must finish what you write.? ?Endless polishing and editing and revising and polishing again and then rewriting and then editing does not make a story perfect?it just makes a story endless.

Remember what I posted a few days ago: ?It doesn?t have to be perfect, but it does have to be finished.

I?ve known writers who have a love affair with a particular story. ?They set out with a promising draft, then they begin polishing . . . and polishing . . . and the story vanishes into a black hole of neverending revisions. ?When I first started publishing novels, I ran a monthly writers? workshop with a group of fellow novelists and short-story writers.? One member brought in a new story?a pretty good one?and we critiqued it, suggested some improvements, and he took it home.? At the next month?s meeting, he brought in a revised version for critique, and we again made our comments.? And again for the next three months.? Ironically, after a certain point, there was no noticeable improvement. ?The story was stuck in an infinite loop.? As far as I know, he never sent it anywhere.

Don?t misunderstand: ?You can?t turn in a sloppy manuscript, and each submission should be as good as you can make it, but there comes a point of diminishing returns in editing your prose. ?Are you becoming obsessive about rewriting and polishing? Are you making cosmetic changes and circular edits that no longer improve the story?? Is it possible you?re simply looking for excuses to put off finishing it? ?It?s done! Send the manuscript to an editor and move on to the next story.

If you spend all your writing time fiddling with one story, you?ll never move on to the next one, and the next.? On with it, already!

I hope you have enjoyed this series of eleven tips to increase your writing productivity.? Some of them many not work for you?they don?t all work for me, all the time?but they are techniques to help you think outside the box.? Try something different and see if you find it effective.? The one absolute piece of writing advice is that authors are all different, and there?s no right way to do it.

?

Source: http://kjablog.com/?p=3483

nba playoff schedule rondo morris claiborne mothers day gifts clippers lisa lampanelli lisa lampanelli

A Coffee Bean Diet Is A Sensible Way To Achieve Your Health ...

Pure Green Coffee Bean Extract may be the a minumum of one having to do with the a variety of if you need now available you will find that be of assistance persons keep their bodyweight at less than control In an all in one world increasingly inundated so that you have fatty what food you?re eating and greasy diets trying if you want to maintain spin out of control concerning one?s health can be the case even more difficult However, persons can take measures you will see that have to worry about and consequently And going on an all in one coffee bean diet plans is always one labor in that direction.

The fact is always that you?re a fast person. Your aids ?re damaged between the two going to be the demands about your pastime and a noble and going to be the obligations relating to family life ? span Trying you will find that be able to get about for exercise or at least you will see that maintain a multi functional positive regimen of healthy the food you eat may certainly not be the case as easy gorgeous honeymoons as well you as a resource box is that gorgeous honeymoons as well numerous persons. However,your family owe a resource box you will experience that yourself so as to draw attention away from your weight down you will notice that a multi function manageable size Pure natural green coffee bean extract can help all your family members must and as a consequence in an all in one sane and reasonably priced way.

Indeed, there has to be that don?t you think reason to are under the impression that obesity is the fact that caused solely based on lack about engage in physical activity and movement Some having to do with by far the most active and energetic persons put everywhere over the obesity as well as reasons that have little you will recognize that have to worry about so that you have how do we much in the way they move as part of your the game regarding the day. Going throughout the an all in one ecological bean nutrition can be of assistance all your family members draw attention away from your body volume under a control It can be especially powerful also those persons which of you ?re frantic professionals and still get unable as a way to draw attention away from going to be the body weight ially.

This can be done on the an all in one way that is always that easy in an effort to manage and that is the fact that ach affordable. We are no longer rarely boy or girl their selves into believing that going to be the products and dietary programs overweight adults are going to want in an effort to how to their extra body weight are free of charge or at least more Many some of these things are quite will set you back and hardly ever within range about the budgets having to do with lots of working persons. Pure efficient coffee bean extract will be the a course of action that is this cheap and powerful

It is that often an absolute must have and for persons you will see that make up their original minds about going to be the merits about a multi function among the most common way relating to managing their health. A Green Coffee Diet is that often a great way you will see that get in shape and believe great about yourself. However, there ?re lot of ways concerning discovering this. Finding an all in one vendor that has to offer you herbal alternative coffee bean extract may not be that even more complicated The place to begin your search is always all around the going to be the around the globe web The on the internet and will allow all your family members you will recognize that bring all regarding the a lot of unique vendors offering this product or service to your computer screen This not only can they allow you to understand more about and examine going to be the not the same thing features having to do with going to be the diet plan on the basis of so as to provide all your family members with an absolute must have about the icelandic sheepdog and things This is not very one of the more essential you will appreciate that going to be the aim concerning informing all your family about going to be the if you desire all your family ?re buying; a resource box is that also vital that all your family members are aware of that going to be the composition relating to any of these things so as you will notice that be sure that your unique health and safety; for the reason that way all your family members are armed providing some one each of them is having to do with going to be the information all your family members will want when all your family consult your a health care provider The on the internet and also enables all your family members to find out going to be the reputation of going to be the vendor you?re purchasing both to and from The best predictor of longterm performance is the fact past performance. The vendor that has an all in one guaranteed stay attuned to regarding delivering and there customer satisfaction could possibly be the one or more more often than not you will find that know your needs and expectations.

Source: http://www.mallonline-canada.com/a-coffee-bean-diet-is-a-sensible-way-to-achieve-your-health-goals.html

Tulane player injured frank ocean fox sports obama speech amber rose kindle fire drew peterson

PhD student position at the Institute of Neurobiology, Univsity of ...

A PhD student position is available in the group of Sven Bogdan at the Institute of Neurobiology, University of M?nster, Germany. Our group is interested in the molecular control of actin dynamics in vivo using Drosophila as a model system. The aim of the project is the functional characterization of ?

?

Note: Please apply for the below job position within 15 day if last date was not mentioned in the post This position was published on Sunday, October 28th, 2012

A PhD student position is available in the group of Sven Bogdan at the Institute of Neurobiology, University of M?nster, Germany.

Our group is interested in the molecular control of actin dynamics in vivo using Drosophila as a model system. The aim of the project is the functional characterization of a novel actin regulator at the cellular and multicellular level in Drosophila.

We are looking for highly motivated students with experience in Drosophila genetics and/or cell biology, molecular biology. We offer an exciting interdisciplinary project based on our combined expertise in cell biology and Drosophila genetics in well-equipped labs with high end imaging microscopes (SIM, SDM, LSM). The position is available for 3 years.

?

How to apply:

PD. Dr. Sven Bogdan: sbogdan@uni-muenster.deWebsite:

http://www.actindynamics.org/cms/index.php?page=sven-bogdan-muenster

http://sfb629.uni-muenster.de/

Contact details for applications:

Applicants should forward a CV, all final exams, a letter of interest, and two letters of reference to PD. Dr. Sven Bogdan: sbogdan@uni-muenster.de.

Source: http://www.jobsinsciences.com/bio-jobs/phd-student-position-at-the-institute-of-neurobiology-univsity-of-munster-germany/

taylor swift zac efron the scream stephen colbert new madrid fault rihanna and chris brown affirmative action helicon

Saturday, October 27, 2012

States Rein in Health Insurance Expenses

Financially strapped state and local governments are saving billions of dollars on health insurance by cutting back on free coverage for employees and raising worker contributions, says USA Today.

  • The advantage government sector employees have had in health benefits over private sector employees has declined from $1,523 in 2007 to $891 in 2012.
  • Similarly, the share of full-time government employees paying nothing for their coverage declined from 39 percent in 2007 to 30 percent in 2012.
  • Yet that number is still higher than the 17 percent of private sector workers that pay nothing for their coverage.
  • Moreover, paycheck withdrawals for health insurance are the same for public and private employees at about $425 a month for the family health coverage.

Government employees still benefit from more generous benefits such as lower copayments and deductibles and more choices.

The reductions in benefits for public sector employees stems from the efforts of Republican governors to reduce the costs of employee benefits. State officials have sparred with public employee unions in places like New Jersey, Ohio, Wisconsin and other states.

Public sector employees are taking the fight to courts and legislatures to protect their benefits. They argue that they have already made sacrifices such as taking wage freezes in order to protect health benefits.

Source: Dennis Cauchon, "States Rein in Health Insurance Expenses," USA Today, October 23, 2012.

?

Browse more articles on Health Issues


Source: http://www.ncpa.org/sub/dpd/index.php?Article_ID=22511

gizmodo cnet britney spears sprint Sam Bacile thursday night football At&t Wireless

Moffitt Researchers find genetic predictors of fatigue for some prostate cancer patients

Moffitt Researchers find genetic predictors of fatigue for some prostate cancer patients [ Back to EurekAlert! ] Public release date: 26-Oct-2012
[ | E-mail | Share Share ]

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Researchers at Moffitt Cancer Center and the University of South Florida have found that men with prostate cancer who receive androgen deprivation therapy may predictably suffer from fatigue if they have single nucleotide polymorphisms in three pro-inflammatory genes. The discovery highlights the importance of personalized medicine, in which therapies are tailored to a patient's genetic profile.

The study appears in the October issue of Brain, Behavior, and Immunity.

"Few studies have examined the role of genes in cancer-related fatigue and none, to our knowledge, have examined genetic variation related to androgen deprivation therapy," said study co-principal investigator Heather S.L. Jim, Ph.D., assistant member of the Health Outcomes and Behavior Program. "We found that prostate cancer patients who carry the variants of the IL6 and TNFA genes and are treated with androgen deprivation therapy are susceptible to heightened fatigue."

Evidence from prostate cancer studies suggests that pro-inflammatory cytokines, which have been linked to fatigue in cancer patients, are influenced by testosterone. At the same time, testosterone inhibits IL6 gene expression. Androgen deprivation therapy restricts testosterone.

"The goal of our study was to examine whether single nucleotide polymorphisms in genes that regulate pro-inflammatory cytokines can predict changes in fatigue in men receiving androgen deprivation therapy," said co-principal investigator Paul B. Jacobsen, Ph.D., associate center director for Cancer Prevention & Control at Moffitt. "We hypothesized that patients displaying variants at these sites would display greater increases in fatigue following initiation of androgen deprivation therapy."

The researchers found that patients with a greater number of variants reported greater increases in fatigue and of longer duration.

"It is still unclear why IL6 and TNFA genotypes affected some aspects of fatigue but not others," Jim said. "While the single nucleotide polymorphisms found in our study were located in predicted transcription factor binding sites that regulate gene expression, a single gene can have many regulatory sites scattered across the genome."

The authors speculated that new single nucleotide polymorphisms may be uncovered that will help to clarify the mechanisms of inflammatory gene transcription as they relate to fatigue in cancer patients. Preliminary findings from this study "represent an important first step in identifying genetic variation as a predictor of fatigue secondary to androgen deprivation therapy," the researchers concluded.

"Early identification of patients with genetic risk factors can enable clinicians to provide timely interventions, behavioral or pharmacologic, to prevent or reduce fatigue," Jacobsen said. "This goal is consistent with personalized cancer treatment tailored to individual gene profiles to maximize benefit and minimize side effects."

###

The study was funded by two grants from the National Cancer Institute: NCI R01-CA132803 and NCI K07-CA138499.

About Moffitt Cancer Center

Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt's excellence in research, its contributions to clinical trials, prevention and cancer control. Since 1999, Moffitt has been listed in U.S. News & World Report as one of "America's Best Hospitals" for cancer. With more than 4,200 employees, Moffitt has an economic impact on the state of nearly $2 billion. For more information, visit MOFFITT.org, and follow the Moffitt momentum on Facebook, twitter and YouTube.

Media release by Florida Science Communications



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Moffitt Researchers find genetic predictors of fatigue for some prostate cancer patients [ Back to EurekAlert! ] Public release date: 26-Oct-2012
[ | E-mail | Share Share ]

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Researchers at Moffitt Cancer Center and the University of South Florida have found that men with prostate cancer who receive androgen deprivation therapy may predictably suffer from fatigue if they have single nucleotide polymorphisms in three pro-inflammatory genes. The discovery highlights the importance of personalized medicine, in which therapies are tailored to a patient's genetic profile.

The study appears in the October issue of Brain, Behavior, and Immunity.

"Few studies have examined the role of genes in cancer-related fatigue and none, to our knowledge, have examined genetic variation related to androgen deprivation therapy," said study co-principal investigator Heather S.L. Jim, Ph.D., assistant member of the Health Outcomes and Behavior Program. "We found that prostate cancer patients who carry the variants of the IL6 and TNFA genes and are treated with androgen deprivation therapy are susceptible to heightened fatigue."

Evidence from prostate cancer studies suggests that pro-inflammatory cytokines, which have been linked to fatigue in cancer patients, are influenced by testosterone. At the same time, testosterone inhibits IL6 gene expression. Androgen deprivation therapy restricts testosterone.

"The goal of our study was to examine whether single nucleotide polymorphisms in genes that regulate pro-inflammatory cytokines can predict changes in fatigue in men receiving androgen deprivation therapy," said co-principal investigator Paul B. Jacobsen, Ph.D., associate center director for Cancer Prevention & Control at Moffitt. "We hypothesized that patients displaying variants at these sites would display greater increases in fatigue following initiation of androgen deprivation therapy."

The researchers found that patients with a greater number of variants reported greater increases in fatigue and of longer duration.

"It is still unclear why IL6 and TNFA genotypes affected some aspects of fatigue but not others," Jim said. "While the single nucleotide polymorphisms found in our study were located in predicted transcription factor binding sites that regulate gene expression, a single gene can have many regulatory sites scattered across the genome."

The authors speculated that new single nucleotide polymorphisms may be uncovered that will help to clarify the mechanisms of inflammatory gene transcription as they relate to fatigue in cancer patients. Preliminary findings from this study "represent an important first step in identifying genetic variation as a predictor of fatigue secondary to androgen deprivation therapy," the researchers concluded.

"Early identification of patients with genetic risk factors can enable clinicians to provide timely interventions, behavioral or pharmacologic, to prevent or reduce fatigue," Jacobsen said. "This goal is consistent with personalized cancer treatment tailored to individual gene profiles to maximize benefit and minimize side effects."

###

The study was funded by two grants from the National Cancer Institute: NCI R01-CA132803 and NCI K07-CA138499.

About Moffitt Cancer Center

Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt's excellence in research, its contributions to clinical trials, prevention and cancer control. Since 1999, Moffitt has been listed in U.S. News & World Report as one of "America's Best Hospitals" for cancer. With more than 4,200 employees, Moffitt has an economic impact on the state of nearly $2 billion. For more information, visit MOFFITT.org, and follow the Moffitt momentum on Facebook, twitter and YouTube.

Media release by Florida Science Communications



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-10/hlmc-mrf102612.php

mega millions results louisville lotto numbers susan powell megamillions winners university of louisville louisville ky

Sandy pounds Bahamas after killing 22 in Caribbean

Resident Antonio Garces tries to recover his belongings from his house destroyed by Hurricane Sandy in Aguacate, Cuba, Thursday Oct. 25, 2012. Hurricane Sandy blasted across eastern Cuba on Thursday as a potent Category 2 storm and headed for the Bahamas after causing at least two deaths in the Caribbean. (AP Photo/Franklin Reyes)

Resident Antonio Garces tries to recover his belongings from his house destroyed by Hurricane Sandy in Aguacate, Cuba, Thursday Oct. 25, 2012. Hurricane Sandy blasted across eastern Cuba on Thursday as a potent Category 2 storm and headed for the Bahamas after causing at least two deaths in the Caribbean. (AP Photo/Franklin Reyes)

Soldiers an rescue workers patrol after the passing of Hurricane Sandy in Santiago de Cuba, Cuba, Thursday Oct. 25, 2012. Hurricane Sandy blasted across eastern Cuba on Thursday as a potent Category 2 storm and headed for the Bahamas after causing at least two deaths in the Caribbean. (AP Photo/Franklin Reyes)

Resident Antonio Garces tries to recover his belongings from his house destroyed by Hurricane Sandy in Aguacate, Cuba, Thursday Oct. 25, 2012. Hurricane Sandy blasted across eastern Cuba on Thursday as a potent Category 2 storm and headed for the Bahamas after causing at least two deaths in the Caribbean. (AP Photo/Franklin Reyes)

Fallen palm trees lie on a road after the hurricane Sandy in Santiago de Cuba, Cuba, Thursday Oct. 25, 2012. Hurricane Sandy blasted across eastern Cuba on Thursday as a potent Category 2 storm and headed for the Bahamas after causing at least two deaths in the Caribbean. (AP Photo/Franklin Reyes)

Locals walk across the flooded streets of La Plaine, Haiti, Thursday, Oct. 25, 2012, after Hurricane Sandy caused flooding and claimed three lives. Hurricane Sandy roared across Cuba overnight, making landfall as a powerful 115-mph storm. Haiti's capital, Port-au-Prince is still feeling the ripple effects, with gusty continuing rain as the Sandy makes its way towards the Bahamas. (AP Photo/The Miami Herald, Carl Juste) MAGS OUT

(AP) ? Hurricane Sandy raged through the Bahamas early Friday after leaving 22 people dead across the Caribbean, following a path that could see it blend with a winter storm to hit the U.S. East Coast with a super-storm next week.

Sandy knocked out power, flooded roads and cut off islands in the storm-hardened Bahamas as it swirled past Cat Island and Eleuthera, but authorities reported no deaths in the scattered archipelago.

"Generally people are realizing it is serious," said Caroline Turnquest, head of the Red Cross in the Bahamas, who said 20 shelters were opened on the main island of New Providence.

Sandy, which weakened to a category 1 hurricane Thursday night, caused havoc in Cuba Thursday, killing 11 people in eastern Santiago and Guantanamo provinces as its howling winds and rain toppled houses and ripped off roofs. Authorities said it was Cuba's deadliest storm since July 2005, when category 5 Hurricane Dennis killed 16 people and caused $2.4 billion in damage.

Sandy also killed one person while battering Jamaica on Wednesday and nine in Haiti, where heavy rains from the storm's outer bands caused flooding in the impoverished and deforested country. Police in the Bahamas said a 66-year-old man died after falling from his roof in upscale Lyford Cay late Thursday while trying to repair a window shutter.

On Friday morning, the hurricane's center was about 15 miles (25 kilometers) east of Great Abaco Island in the Bahamas and 480 miles (770 kilometers) south-southeast of Charleston, South Carolina. Sandy was moving northwest at 10 mph (17 kph) with maximum sustained winds near 80 mph (130 kph).

Government officials in the Bahamas said the storm seems to have inflicted the greatest damage on Exuma, where there were reports of downed trees, power lines and damage to homes.

With the storm projected to hit the Atlantic coast early Tuesday, there was a 90 percent chance that most of the U.S. East Coast would get steady gale-force winds, flooding, heavy rain and maybe snow starting Sunday and stretching past Wednesday, U.S. forecaster Jim Cisco said.

A new tropical storm watch was issued early Friday for a section of the U.S. East Coast extending from Savannah, Ga., northward to North Carolina's Outer Banks.

Sandy was expected to remain a hurricane almost until reaching the U.S. shoreline, probably early Tuesday.

In the Bahamas, power was out on Acklins Island and most roads there were flooded, government administrator Berkeley Williams said.

On Ragged Island in the southern Bahamas, the lone school was flooded.

"We have holes in roofs, lost shingles and power lines are down," said Charlene Bain, local Red Cross president. "But nobody lost a life, that's the important thing."

Steven Russell, an emergency management official in Nassau, said docks on the western side of Great Inagua island had been destroyed and the roof of a government building was partially ripped off.

Sooner Halvorson, a 36-year-old hotel owner from Colorado who recently moved to the Bahamas, said she and her husband, Matt, expected to ride out the storm with their two young children, three cats, two dogs and a goat at their Cat Island resort.

"We brought all of our animals inside," she said, though she added that a horse stayed outside. "She's a 40-year-old horse from the island. She's been through tons of hurricanes."

In an announcement at the end of Cuba's Thursday night newscast, Cuban authorities said the island's 11 dead included a 4-month-old boy who was crushed when his home collapsed and an 84-year-old man in Santiago province.

There were no reports of injuries at the U.S. naval base at Guantanamo Bay in Cuba, but there were downed trees and power lines, said Kelly Wirfel, a base spokeswoman. Officials canceled a military tribunal session scheduled for Thursday for the prisoner charged in the 2000 attack on the Navy destroyer USS Cole.

In Haiti, Joseph Edgard Celestin, a spokesman for the civil protection office, said the country's death toll stood at nine, including three people who died while trying to cross storm-swollen rivers in southwestern Haiti. He did not provide specifics of how other people died.

Officials reported flooding across Haiti, where many of the 370,000 people still displaced by the devastating 2010 earthquake scrambled for shelter. More than 1,000 people were evacuated from 11 quake settlements, according to the International Organization for Migration.

Sandy was blamed for the death of an elderly man in Jamaica.

___

Associated Press writers Danica Coto in San Juan, Puerto Rico; David McFadden in Kingston, Jamaica; Trenton Daniel in Port-au-Prince, Haiti; Ben Fox in Guantanamo, Cuba; Seth Borenstein in Washington; Juan McCartney in Nassau, Bahamas; and Fernando Gonzalez, Paul Haven, Andrea Rodriguez and Anne-Marie Garcia in Havana contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-10-26-Tropical%20Weather/id-47f0d35e0c1c4f42ace630802fe02fbe

superpac steve appleton bishop eddie long madonna give me all your luvin video roseanne barr president green party day 26

Amended traffic law awaits GG's endorsement | Antigua Observer ...

By Martina Johnson - Friday, October 26th, 2012.

ST JOHN?S, Antigua ? Senators yesterday gave the stamp of approval to make driving without a licence an unlawful act once again ? 12 years after the offence was unintentionally removed from the law books.

But before police could resume slapping handcuffs on people for driving without a licence, the amendment must be endorsed by the governor general.

Once the approval is given, anyone caught in breach of the law under the Vehicle and Road Traffic (Amendment) Act 2012 would again face a penalty of up to two years in jail and/or a fine not exceeding $5,000.

Efforts to correct the mistake come several months after Commissioner of Police Vere Browne brought it to the attention of the Ministry of Legal Affairs.

Senator and attorney Sylvia O?Marde expressed disappointment it went unnoticed for so long.

?As a lawyer I?m a little disheartened that something like this happened and not one of our lawyers, including myself, in Antigua noticed this grave matter. It is a serious matter ? luckily this has been caught and happily we are here to correct it,? O?Marde said.

Senator Lennox Weston expressed a similar view, adding that it is also unfortunate that the mistake escaped legislators, magistrates and police for over a decade.

But while the authorities are addressing the matter, there was no response to queries from Senator Arthur Nibbs, who asked what can be done with respect to individuals convicted during the 12-year period, when driving without a licence was not an offence.

Attorney Steadroy ?Cutie? Benjamin, had earlier suggested persons may be entitled to sue.

Ever since the police noted the error, they ceased charging individuals for driving without a licence, but continued to prosecute them for driving without insurance.

That is because an individual who drives without a licence is not covered by insurance.

It was on July 13, 2000 that authorities made amendments to the Act and accidentally repealed Section 30, Cap 460, that initially made it an offence to drive without a licence.

The amendment had also removed the penalties.

(More in today?s Daily OBSERVER)

Source: http://www.antiguaobserver.com/?p=83034

vanessa marcil 49 ers frank gore frank gore nfl games jesus montero hiroki kuroda

Friday, October 26, 2012

Ravens fined $20K for not listing Reed's injury

Houston Texans running back Arian Foster (23) is pulled down by Baltimore Ravens' Ed Reed (20) during the first quarter of an NFL football game Sunday, Oct. 21, 2012, in Houston. (AP Photo/Patric Schneider)

Houston Texans running back Arian Foster (23) is pulled down by Baltimore Ravens' Ed Reed (20) during the first quarter of an NFL football game Sunday, Oct. 21, 2012, in Houston. (AP Photo/Patric Schneider)

(AP) ? The NFL fined the Baltimore Ravens $20,000 Friday for not listing safety Ed Reed on the team's injury report.

Reed publicly acknowledged his right shoulder injury Oct. 17, a few days before the Ravens played Houston and said it could be affecting his play. The Pro Bowl safety played during practices and games after the injury occurred.

The league he should have been listed on the injury report with a shoulder injury and was fully participating in practice.

The NFL's policy on injury reports states that players with "significant or noteworthy injuries must be listed on the report, even if the player takes all the reps in practice." The rule covers players the team is certain will play in upcoming games.

Reed has played in every game this season. He has 30 tackles, two interceptions ? including a 34-yard return for a touchdown ? and seven passes defensed.

Washington and Buffalo were fined $20,000 each for similar infractions last week.

The Redskins were fined for not properly updating media on quarterback Robert Griffin III's status during a game against Atlanta on Oct. 7. He left with a head injury that turned out to be a mild concussion.

The Bills failed to list defensive end Mario Williams on the injury report while he was being treated for a sprained left wrist. Williams said on Oct. 3 that the wrist had been bothering him for weeks and limiting his play.

___

Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-10-26-Ravens-Injury%20Fine/id-750aa73910b34a9bb2ad65122d1dea98

chris cooley condoleezza rice bill cosby Perry Hall High School us open Hurricane Isaac 2012 bill nye

Stern to retire as NBA Commissioner in 2014

NEW YORK (AP) ? David Stern spent nearly 30 years growing the NBA, turning a league that couldn't even get its championship series on live prime-time TV into a projected $5 billion a year industry.

Confident the NBA is in good shape and certain he has found someone who can make it even better, Stern is ready to end one of the most successful and impactful careers in sports history.

Stern will retire as commissioner Feb. 1, 2014, 30 years to the day after taking charge of the league, and be replaced by Deputy Commissioner Adam Silver.

"I decided that things are in great shape and there's an organization in place that will ultimately be led by Adam that is totally prepared to take it to the next level," Stern said Thursday during a press conference following the league's board of governors meeting.

It's hard to be any better than Stern, perhaps the model sports commissioner.

Name an important policy in the NBA ? drug testing, salary cap, even a dress code ? and Stern had a hand in it. A lawyer by trade, he was a fearless negotiator against players and referees, but also their biggest defender any time he felt they were unfairly criticized.

"For all the things you've done for the NBA and for sports generally, I think there's no doubt that you'll be remembered as the best of all-time as commissioners go and you've set the standard, I think not even just for sports league commissioners, but for CEOs in any industry," Silver told Stern sitting to his left on a podium.

Stern told owners of his plans during their two days of meetings, and the board unanimously decided Silver would be his successor. Owners will begin negotiations with the 50-year-old Silver in hopes of having a contract completed by their next meeting in April.

Stern, who turned 70 last month, became commissioner on Feb. 1, 1984. He has been the NBA's longest-serving commissioner, establishing the league's brand around the world, presiding over team expansion and overseeing the establishment of the WNBA and the NBA Development League.

"There is no debate that David Stern has earned his spot in the pantheon of sports commissioners. Deservedly, his name and reputation will always be synonymous with the phenomenal growth and success of the NBA over the last three decades," union executive director Billy Hunter said in a statement. "His absence will surely be felt by anyone connected to the NBA and the sport of basketball, although clearly the league will be left in very capable hands with the appointment of Adam Silver as the next commissioner."

Seven franchises have been added under Stern and the league has seen a 30-fold increase in revenues. Stern insisted the NBA have a presence on social media, and the league and players have more than 270 million likes and followers on Facebook and Twitter.

"There are all kinds of other business metrics we could look at that would define David as one of the great business leaders of our time," Silver said.

Stern said he decided on his plans about six months ago, having guided the league through a lockout that ended nearly a year ago. He didn't want to leave until the labor deal was completed or until he was confident there was a successor in place, and both are done. Silver has been the league's No. 2 since 2006, and both Stern and league owners praise his abilities.

"I don't know what else to say other than to recite what I told the owners yesterday in executive session," Stern said. "I told them that it's been a great run, it will continue for another 15 months, that the league is in, I think, terrific condition."

Stern is the one who got it there, taking over what was a second-rate league with little-to-no TV presence ? the NBA Finals were on tape delay in the early 1980s ? and making basketball one of the world's most popular sports.

"A couple of things that stand out to me is that David has been, in my estimation, the type of commissioner that has set the standard not only for the NBA but for all of the sports," said Minnesota Timberwolves owner Glen Taylor, the outgoing chairman of the board of governors. "We have done so many wonderful things in the organization. The marketing, leadership, the brand recognition, going international way before our times, and David has led that."

Taylor said there's been a "40-fold" increase in revenues from the league's national TV contract, and that the average player salary will have had grown from $250,000 when Stern took over to $5 million by the end of the current collective bargaining agreement.

Stern was the league's outside counsel from 1966-78, then its general counsel before becoming executive vice president of business and legal affairs from 1980-84. He replaced Larry O'Brien to become the league's fourth commissioner, getting a boost in taking the game mainstream with the popularity of Magic Johnson and Larry Bird, and soon Michael Jordan. The league began marketing its stars, and Stern found the desire for them was greatest in some far-away lands.

The real explosion came in 1992, when those three headed the Dream Team that led the U.S. to the Olympic basketball gold medal while winning fans around the world. The NBA has gone on to play games in 17 countries, staging 114 international games.

"He's done a remarkable job," Major League Baseball Commission Bud Selig said at the World Series. "To think of what the NBA was when he came in and what it is today, most people judge him very very highly."

There were rough patches, particularly the brawl between Indiana Pacers players and Detroit Pistons fans in 2004, and the betting scandal involving former referee Tim Donaghy. Stern had already passed off most of the heavy lifting to Silver by last year, but he was the one absorbing the criticism during the lockout for the second shortened season in his tenure.

He sometimes appeared worn down during the negotiations, even missing one critical bargaining session while sick, but insists he's got plenty of energy to keep working now.

"I feel great," Stern said. "I'm enjoying my job, but I'm looking forward to doing some other things. I'm stepping down, I'm not retiring."

Stern just recently returned from China, Germany and Italy, and plans another overseas trip next season, and will remain an adviser to the league in retirement on international matters.

"We just think that his leadership will be important to our future," Taylor said.

It's meant everything to the league's past.

The league has reported huge increases in ticket and merchandise sales, and TV ratings are at an all-time high. Last season's lockout, the second time the league lost games to a work stoppage, hardly made a dent in the league's business or in fans' interest.

But even for Stern, business has always taken a back seat to basketball. He's sought changes to improve play, such as the elimination of isolation play that bored him, to implementing penalties that go into effect this season for flopping.

"For the most part it's been a series of extraordinary experiences and enormous putting together of pieces of a puzzle and it goes on forever," Stern said. "And there will always be another piece of the puzzle and so the question is at what point do you decide that, let someone else do it? That's the point that I'm at now."

Taylor and Spurs owner Peter Holt, who is replacing him as board chairman, said the owners will work to have a contract with Silver by April. Silver came to the NBA 20 years ago and served a variety of positions before becoming the deputy commissioner in 2006. He was the lead negotiator during the lockout and Stern has relied more heavily on him in recent years, even turning to Silver to answer questions on tougher topics.

Stern said he wouldn't leave until he knew there was a successor ready, and he has repeatedly said Silver is ready for that role. Stern said he would always remain available to take a call and help the league.

"Life is a journey and it's been a spectacular journey," Stern said. "Each step along the way there are things that you have to do, things that you maybe wish you hadn't done. But I don't keep that list, and so I'm totally pleased and I'm particularly pleased with the transition of which we're now embarking."

Source: http://news.yahoo.com/stern-retire-nba-commissioner-2014-192855433--spt.html

baltimore ravens atlanta falcons space shuttle new york courtney upshaw russell wilson catch me if you can delmon young arrested

Reclaiming rare earths: Improving process to recycle rare-earth materials

ScienceDaily (Oct. 24, 2012) ? Recycling keeps paper, plastics, and even jeans out of landfills. Could recycling rare-earth magnets do the same? Perhaps, if the recycling process can be improved.

Scientists at the U.S. Department of Energy's (DOE) Ames Laboratory are working to more effectively remove the neodymium, a rare earth element, from the mix of other materials in a magnet. Initial results show recycled materials maintain the properties that make rare-earth magnets useful.

The current rare earth recycling research builds on Ames Laboratory's decades of rare-earth processing experience. In the 1990s, Ames Lab scientists developed a process that uses molten magnesium to remove rare earths from neodymium-iron-boron magnet scrap. Back then, the goal was to produce a mixture of magnesium and neodymium because the neodymium added important strength to the alloy, rather than separate out high-purity rare earths because, at the time, rare earth prices were low.

But rare earth prices increased ten-fold between 2009 and 2011 and supplies are in question. Therefore, the goal of today's rare-earth recycling research takes the process one step farther.

"Now the goal is to make new magnet alloys from recycled rare earths. And we want those new alloys to be similar to alloys made from unprocessed rare-earth materials," said Ryan Ott, the Ames Laboratory scientist leading the research. "It appears that the processing technique works well. It effectively removes rare earths from commercial magnets."

Ott's research team also includes Ames Laboratory scientist Larry Jones and is funded through a work for others agreement with the Korea Institute of Industrial Technology. The research group is developing and testing the technique in Ames Lab's Materials Preparation Center, with a suite of materials science tools supported by the DOE Office of Science.

"We start with sintered, uncoated magnets that contain three rare earths: neodymium, praseodymium and dysprosium," said Ott. "Then we break up the magnets in an automated mortar and pestle until the pieces are 2-4 millimeters long.

Next, the tiny magnet pieces go into a mesh screen box, which is placed in a stainless-steel crucible. Technicians then add chunks of solid magnesium.

A radio frequency furnace heats the material. The magnesium begins to melt, while the magnet chunks remain solid.

"What happens then is that all three rare earths leave the magnetic material by diffusion and enter the molten magnesium," said Ott. "The iron and boron that made up the original magnet are left behind."

The molten magnesium and rare-earth mixture is cast into an ingot and cooled. Then they boil off the magnesium, leaving just the rare earth materials behind.

"We've found that the properties of the recycled rare earths compare very favorably to ones from unprocessed materials," said Ott. "We're continuing to identify the ideal processing conditions."

The next step is optimizing the extraction process. Then the team plans to demonstrate it on a larger scale.

"We want to help bridge the gap between the fundamental science and using this science in manufacturing," said Ott. "And Ames Lab can process big enough amounts of material to show that our rare-earth recycling process works on a large scale."

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by DOE/Ames Laboratory.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/CLvDkhbELrQ/121024175520.htm

dick cheney heart umf peter frampton elite eight stephon marbury the lion king suzanne collins

Thursday, October 25, 2012

Scientists target bacterial transfer of resistance genes

ScienceDaily (Oct. 24, 2012) ? The bacterium Streptococcus pneumoniae -- which can cause pneumonia, meningitis, bacteremia and sepsis -- likes to share its antibiotic-defeating weaponry with its neighbors. Individual cells can pass resistance genes to one another through a process called horizontal gene transfer, or by "transformation," the uptake of DNA from the environment.

Now researchers report that they can interrupt the cascade of cellular events that allows S. pneumoniae to swap or suck up DNA. The new findings, reported in the journal PLoS ONE, advance the effort to develop a reliable method for shutting down the spread of drug resistance in bacteria.

"Within the last few decades, S. pneumoniae has developed resistance to several classes of antibiotics," said University of Illinois pathobiology professor Gee Lau, who led the study. "Importantly, it has been shown that antibiotic stress -- the use of antibiotics to treat an infection -- can actually induce the transfer of resistance genes among S. pneumoniae. Our approach inhibits resistance gene transfer in all strains of S. pneumoniae, and does so without increasing selective pressure and without increasing the likelihood that resistant strains will become dominant."

Lau and his colleagues focused on blocking a protein that, when it binds to a receptor in the bacterial cell membrane, spurs a series of events in the cell that makes the bacterium "competent" to receive new genetic material. The researchers hypothesized that interfering with this protein (called CSP) would hinder its ability to promote gene transfer.

In previous work published late last year in the journal PLoS Pathogens, Lau's team identified proteins that could be made in the lab that were structurally very similar to the CSP proteins. These artificial CSPs can dock with the membrane receptors, block the bacterial CSPs' access to the receptors and reduce bacterial competence, as well as reducing the infectious capacity of S. pneumoniae.

In the new study, the researchers fine-tuned the amino acid structure of more than a dozen artificial CSPs and tested how well they inhibited the S. pneumoniae CSPs. They also tested their ability (or, more desirably, their inability) to mimic the activity of CSPs in bacterial cells.

"The chemical properties of individual amino acids in a protein can greatly influence the protein's activity," Lau said.

The team identified several artificial CSPs that both inhibited the bacterial CSPs and reduced S. pneumoniae competence by more than 90 percent.

"This strategy will likely help us reduce the spread of antibiotic-resistance genes among S. pneumoniae and perhaps other species of streptococcus bacteria," Lau said.

The study team included researchers from Sun-Yat-Sen University in Guangdong, China. The National Institutes of Health and the University of Illinois Research Board Arnold O. Beckman Research Endowment partially supported this work.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by University of Illinois at Urbana-Champaign.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Chaohui Duan, Luchang Zhu, Ying Xu, Gee W. Lau. Saturated Alanine Scanning Mutagenesis of the Pneumococcus Competence Stimulating Peptide Identifies Analogs That Inhibit Genetic Transformation. PLoS ONE, 2012; 7 (9): e44710 DOI: 10.1371/journal.pone.0044710

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/0I6n2p7v5nc/121024133454.htm

corned beef and cabbage diners drive ins and dives jeff who lives at home 49ers news saint louis university leprechaun night at the museum

Bobby Brown arrested in Los Angeles; DUI suspicion

FILE - In this Feb. 18, 2012 file photo, singer Bobby Brown, former husband of the late Whitney Houston performs at Mohegan Sun Casino in Uncasville, Conn. Brown has been arrested on suspicion of drunken driving for the second time this year. Police say he was booked Wednesday, Oct. 24, on suspicion of driving under the influence at the Van Nuys jail but was later released. (AP Photo/Joe Giblin, File)

FILE - In this Feb. 18, 2012 file photo, singer Bobby Brown, former husband of the late Whitney Houston performs at Mohegan Sun Casino in Uncasville, Conn. Brown has been arrested on suspicion of drunken driving for the second time this year. Police say he was booked Wednesday, Oct. 24, on suspicion of driving under the influence at the Van Nuys jail but was later released. (AP Photo/Joe Giblin, File)

(AP) ? Bobby Brown has been arrested on suspicion of drunken driving for the second time this year.

Los Angeles police spokeswoman Venus Hall says the singer's car was stopped in the Topanga area at around 1 a.m. Wednesday.

Police say he was booked on suspicion of driving under the influence at the Van Nuys jail but was later released.

A representative for Brown could not immediately be contacted.

The 43-year-old pleaded no contest to DUI earlier this year following a March arrest in Los Angeles. Under a plea agreement, Brown checked himself into a rehabilitation center in August.

Brown's first album in 14 years came out this summer.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2012-10-24-Bobby%20Brown-DUI/id-a331199128ae4b2d821a241fc454ace7

road house occupy oakland occupy oakland morgellons disease arik armstead sag awards red carpet torrey pines

barabbas paracelsus: Buy Franklin Sports Recreational Badminton ...

Best Cheap Franklin Sports Recreational Badminton/Volleyball Set Shop

Fantastic selection of Franklin Sports Recreational Badminton/Volleyball Set and essential accessories. You can find wide variety of products fit with your style. And also buyers?s? testimony of Franklin Sports Recreational Badminton/Volleyball Set right here at our Website.

?

?

The Franklin Sports Recreational Badminton/Volleyball Set descrition 4 Tempered steel rackets with Hy-sheep string and a pair of yellow shuttlecocks. The Franklin Sports Recreational Volleyball/Badminton Combo set is a will need to have for each outdoor. This set embodys the complete thing you want for a domestic volleyball game or a 2 on 2 badminton sport. The pole set adjusts to 61? assembled peak. Carry/storage bag included..

Franklin Sports Recreational Badminton/Volleyball Set Feature

  • Net is 20-Feet X 1.5-Feet X 1.5-Inch
  • Includes Official size vinyl volleyball with inflating pump and needle, lift bag included
  • Poles are .75-Inch diameter octagon, virgin PVC with 61-Inch assembled height
  • Includes 6 yellow styrene floor stakes, 2 top and a pair of heart guy ropes and three sided tape construction
  • 4 Tempered metal rackets with Hy-sheep string and a pair of yellow shuttlecocks
  • 4 Tempered steel rackets with Hy-sheep string and a pair of yellow shuttlecocks. The Franklin Sports Recreational Volleyball/Badminton Combo set is a will need to have for each outdoor. This set embodys the complete thing you want for a domestic volleyball game or a 2 on 2 badminton sport. The pole set adjusts to 61? assembled peak. Carry/storage bag included..

    .

    The Franklin Sports Recreational Volleyball/Badminton Combo set is a must have for each outside. This set embodys the entire lot you need for a household volleyball game or a 2 on 2 badminton recreation. The pole set adjusts to 61? assembled height. Carry/storage bag included.

    This website is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to amazon.com

    Source: http://comparison-shopping-site.com/buy-franklin-sports-recreational-badmintonvolleyball-set-online-shop/

    2012 dunk contest edgar vs henderson berkshire hathaway ufc 144 james jones james jones aladdin

    Source: http://barabbas-paracelsus.blogspot.com/2012/10/buy-franklin-sports-recreational.html

    nfl live saints vs 49ers vanessa marcil 49 ers frank gore frank gore nfl games

    Wednesday, October 24, 2012

    Good Reads: A lesson for democracy, lost and found on Google Earth, and the next Arab uprising

    This week's good reads include words of wisdom from Myanmar's Aung San Suu Kyi, using the Internet and applied mathematics to find the long road home, and a profile of Egyptian courage.

    By Cricket Fuller,?Staff writer / October 12, 2012

    Myanmar opposition leader Aung San Suu Kyi (c.) leaves a branch office of her National League for Democracy party during her visit to Thone Gwa township in Yangon, Myanmar, Thursday, Oct. 11.

    Khin Maung Win/AP

    Enlarge

    Larry Diamond writes in the Atlantic of the recent 17-day US tour by Myanmar (Burma) pro-democracy leader Aung San Suu Kyi ? the first since her release from house arrest in November 2010.

    Skip to next paragraph

    Recent posts

    ' + google_ads[0].line2 + '
    ' + google_ads[0].line3 + '

    '; } else if (google_ads.length > 1) { ad_unit += ''; } } document.getElementById("ad_unit").innerHTML += ad_unit; google_adnum += google_ads.length; return; } var google_adnum = 0; google_ad_client = "pub-6743622525202572"; google_ad_output = 'js'; google_max_num_ads = '1'; google_feedback = "on"; google_ad_type = "text"; google_adtest = "on"; google_image_size = '230x105'; google_skip = '0'; // -->

    Mr. Diamond writes that Ms. Aung San Suu Kyi?s ?moral authority has grown through personal suffering and sacrifice? after decades of house arrest and persecution under the military junta in Myanmar, where a fledging democracy is now beginning to take hold.

    But it is Aung San Suu Kyi?s ?spirit of pragmatism and dialogue? that holds a relevant lesson for American politics. As she told her fellow Burmese in the audience during her American tour, ?We must learn to compromise without regarding it as humiliation.?

    When Aung San Suu Kyi was asked if she aspires to rule her country, Diamond noted that ?rather than shying away from politics, she embraced it. ?You should think of me as a political party leader. I was a politician before I was a ?democracy icon.? ?

    Diamond concludes, ?At a time of rampant cynicism about parties and politicians in the United States, it is invigorating to have a ?democracy icon? remind us that politics can be a noble calling ? and an indispensable means for advancing the public good.?

    Commentators have done plenty of hand-wringing over the Internet?s corrosive effects on civil society. But not to be neglected are the triumphs of the digital realm ? and its sometimes life-changing human impacts.

    Vanity Fair?s David Kushner found one such story in the incredible saga of Saroo Brierley. As a 5-year-old in India, he was separated from his older brother at a train station, and through a series of dramatic turns, found himself lost among the poor and homeless on the streets of Calcutta. Taken in by an orphanage, he was eventually adopted by Australian parents.

    Mr. Brierley adjusted well to his new life, but after graduating from college in 2009, he hit a rough patch: ?After years of ignoring his past, it finally came crashing back ? the desire to find his roots, and himself.?

    Enter Google Earth. Brierley used the program?s satellite imagery to search for his home village in India ? whose geographic location and name he did not know. ?All he had was a laptop and some hazy memories, but Saroo was going to try.?

    Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/TgfILH2T2o0/Good-Reads-A-lesson-for-democracy-lost-and-found-on-Google-Earth-and-the-next-Arab-uprising

    primary results dale earnhardt jr michigan primary school shooting daytona 500 winner cleveland plain dealer barry sanders

    Tiny pores in graphene could give rise to membranes

    ScienceDaily (Oct. 23, 2012) ? Much has been made of graphene's exceptional qualities, from its ability to conduct heat and electricity better than any other material to its unparalleled strength: Worked into a composite material, graphene can repel bullets better than Kevlar. Previous research has also shown that pristine graphene -- a microscopic sheet of carbon atoms arranged in a honeycomb pattern -- is among the most impermeable materials ever discovered, making the substance ideal as a barrier film.

    But the material may not be as impenetrable as scientists have thought. By engineering relatively large membranes from single sheets of graphene grown by chemical vapor deposition, researchers from MIT, Oak Ridge National Laboratory (ORNL) and elsewhere have found that the material bears intrinsic defects, or holes in its atom-sized armor. In experiments, the researchers found that small molecules like salts passed easily through a graphene membrane's tiny pores, while larger molecules were unable to penetrate.

    The results, the researchers say, point not to a flaw in graphene, but to the possibility of promising applications, such as membranes that filter microscopic contaminants from water, or that separate specific types of molecules from biological samples.

    "No one has looked for holes in graphene before," says Rohit Karnik, associate professor of mechanical engineering at MIT. "There's a lot of chemical methods that can be used to modify these pores, so it's a platform technology for a new class of membranes."

    Karnik and his colleagues, including researchers from the Indian Institute of Technology and King Fahd University of Petroleum and Minerals, have published their results in the journal ACS Nano.

    Karnik worked with MIT graduate student Sean O'Hern to look for materials "that could lead to not just incremental changes, but substantial leaps in terms of the way membranes perform." In particular, the team cast around for materials with two key attributes, high flux and tunability: that is, membranes that quickly filter fluids, but are also easily tailored to let certain molecules through while trapping others. The group settled on graphene, in part because of its extremely thin structure and its strength: A sheet of graphene is as thin as a single atom, but strong enough to let high volumes of fluids through without shredding apart.

    The team set out to engineer a membrane spanning 25 square millimeters -- a surface area that is large by graphene standards, holding about a quadrillion carbon atoms. They used graphene synthesized by chemical vapor deposition, borrowing on expertise from the research group of Jing Kong, the ITT Career Development Associate Professor of Electrical Engineering at MIT. The team then developed techniques to transfer the graphene sheet to a polycarbonate substrate dotted with holes.

    Once the researchers successfully transferred the graphene, they began to experiment with the resulting membrane, exposing it to flowing water containing molecules of varying sizes. They theorized that if graphene were indeed impermeable, the molecules would be blocked from flowing across. However, experiments showed otherwise, as researchers observed salts flowing through the membrane.

    As another test, the team exposed a copper foil with graphene grown on it to a chemical agent that dissolves copper. Instead of protecting the metal, graphene let the agent through, corroding the underlying copper. To test the size of the pores within graphene, the group attempted to filter water with larger molecules. It appeared that there was a limit to the size of the pores, as larger molecules were unable to pass through the membrane.

    As a final experiment, Karnik and O'Hern observed the actual holes in the graphene membrane, looking at the material through a high-powered electron microscope at ORNL in collaboration with Juan-Carlos Idrobo. They found that pores ranged in size from about 1 to 12 nanometers -- just wide enough to selectively let some small molecules through.

    "Right now we know from this characterization how the graphene behaves, and what kind of intrinsic pores it has," Karnik says. "In some sense it's the first step to practically realizing graphene-based membranes."

    Karnik adds that a near-term application for such membranes may include a portable sensor in which a layer of graphene "could shield the sensor from the environment," letting through only a molecule or contaminant of interest. Another use may be in drug delivery, with graphene, dotted with pores of a determined size, delivering therapies in a controlled release.

    "We're right now in the process of transferring more graphene to different substrates and making holes of our own, making a viable membrane for water filtration," O'Hern says.

    Scott Bunch, an assistant professor of mechanical engineering at the University of Colorado, says the group's results are the first demonstration that graphene bears defects. The membrane developed by the group "has the potential to be a revolutionary membrane" that separates particles at the molecular scale.

    "The issue that now needs to be addressed is whether one can discriminate between smaller molecules," Bunch says. "Once this happens, graphene membranes will eventually live up to the truly remarkable properties that they promise."

    Other researchers involved in the work are Cameron Stewart, Michael Boutilier, Sreekar Bhaviripudi, Sarit Das, Tahar Laoui and Muataz Atieh. This work was funded by the King Fahd University of Petroleum and Minerals through the Center for Clean Water and Clean Energy at MIT and KFUPM, and was also supported by the ORNL ShaRE program.

    Share this story on Facebook, Twitter, and Google:

    Other social bookmarking and sharing tools:


    Story Source:

    The above story is reprinted from materials provided by Massachusetts Institute of Technology. The original article was written by Jennifer Chu, MIT News Office.

    Note: Materials may be edited for content and length. For further information, please contact the source cited above.


    Note: If no author is given, the source is cited instead.

    Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/qhfiGGwAD5A/121023124522.htm

    amy schumer Prince Harry Vegas pictures Avril Lavigne Microsoft Tropical Storm Isaac amber portwood Phyllis Diller